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Información Importante de Seguridad
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The symptoms of PBC can get in the way of daily life

If your liver isn’t working as it should because of PBC, you might experience symptoms that affect your day-to-day routines without realizing they’re related to liver function.

Some of the most common symptoms are:

Severe itching icon

Severe itching

Fatigue icon

Fatigue

Brain fog icon

Brain fog

Body pain icon

Body pain

Symptoms can vary and develop over time

Every person with PBC has a unique experience, including the way their symptoms appear. While some people don’t have symptoms at diagnosis, many eventually develop symptoms. Whatever your experience may be, your symptoms are real and deserve attention and support. 
The severity of your PBC is not related to whether your symptoms are mild, moderate, or severe.

Itching and fatigue from PBC can get in the way of the things you need and want to do every day

Some symptoms of PBC are more than just uncomfortable—they can deeply affect your daily life and well-being. These symptoms can be overwhelming, but know that you’re not the only one feeling this way. Many others with PBC understand what you’re going through.

Severe itching icon

Severe itching can be accompanied with stinging and burning, interfering with daily activities.

Up to
70% 
have itching that is

sometimes severe

Up to
78% 
have fatigue that feels 
worse than normal

Fatigue icon

People often describe PBC fatigue as severe exhaustion that doesn’t seem to go away.

Are you experiencing these symptoms?

It may be helpful to see how other people with PBC are navigating their treatment journey. Watch this video to see Cecilia’s PBC journey unfold.

Your experience matters—talk to your doctor about your symptoms

Knowing and sharing your symptoms with your doctor can help them in creating a treatment plan that works for you.

Doctor discussion guide

Need help discussing and evaluating your current treatment plan? Use the discussion guide below to help navigate the conversation with your doctor.

Starting the discussion can feel intimidating—but even a little preparation can make a big difference. You’ve got this!

Download guide

Discover how IQIRVO works

See how IQIRVO is different from other treatment options.
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Indication and Important Safety Information

What is IQIRVO® used for?

IQIRVO is a prescription medicine used to treat primary biliary cholangitis (PBC) in combination with ursodeoxycholic acid (UDCA) in adults who have not responded well to UDCA, or used alone in patients unable to tolerate UDCA.

IQIRVO is not recommended for use in people who have symptoms or signs of advanced liver disease. It is not known if taking IQIRVO will improve your chance of survival or prevent liver decompensation.

It is not known if IQIRVO is safe and effective in children under 18 years of age.

What Warnings should I know about IQIRVO?

  • IQIRVO can cause muscle problems (myalgia, myopathy, rhabdomyolysis) and muscle pain that can be severe. Treatment with IQIRVO may cause muscle pain or worsen existing pain and can increase the level of an enzyme in your blood called creatine phosphokinase (CPK); both can be a sign of muscle damage. If there is new or worsening muscle pain, your healthcare provider may examine you and perform a blood test. Stop taking IQIRVO and call your healthcare provider right away if you have any of the following signs or symptoms: severe muscle pain, unexplained soreness, unexplained muscle weakness, or dark, reddish urine.
  • IQIRVO may increase the risk of bone fractures. Tell your healthcare provider about any bone fractures, or if you develop pain, or have changes in your ability to move around.
  • IQIRVO may cause harm to an unborn baby when taken during pregnancy. Women taking IQIRVO who can become pregnant should use effective birth control during treatment and for 3 weeks after the last dose of IQIRVO. Talk to your healthcare provider about birth control methods that may be right for you. Tell your healthcare provider right away if you become pregnant or think you may be pregnant.
  • IQIRVO can cause liver problems and abnormal liver blood test results. Your healthcare provider should do tests before starting and during treatment with IQIRVO to check your liver function. Tell your healthcare provider right away if you experience any of the following during treatment with IQIRVO: swelling of your stomach-area (abdomen), yellowing of your skin or whites of your eyes, black, tarry, or bloody stools, mental changes such as confusion, being sleepier than usual or harder to wake up, slurred speech, mood swings, or changes in personality, or coughing up or vomiting blood, or your vomit looks like coffee grounds. If you have severe stomach-area (abdomen) pain, nausea, vomiting, diarrhea, loss of appetite or weight loss, new or worsening fatigue, weakness, fever and chills, light-headedness, or less frequent urination, tell your healthcare provider right away.
  • Some people taking IQIRVO had allergic reactions, which may include rash, trouble breathing, itching, or swelling of your face, lips, tongue, or throat. If you experience any of these, stop taking IQIRVO, call your healthcare provider right away or go to the nearest hospital emergency room.
  • IQIRVO can cause blockage of the bile duct and may increase your risk of gallstones. Call your healthcare provider right away if you develop pain in the upper right stomach area or yellowing of the skin.

You should not use IQIRVO if you:

  • Have advanced liver disease.
  • Are pregnant or plan to become pregnant. IQIRVO can harm your unborn baby. You should not become pregnant during treatment with IQIRVO.
  • Are breastfeeding or plan to breastfeed. It is not known if IQIRVO passes into your breast milk. Talk with your healthcare provider about the best way to feed your baby if you take IQIRVO.

What are the side effects of IQIRVO?

The most common side effects of IQIRVO include weight gain, diarrhea, stomach pain, nausea, vomiting, joint pain, constipation, muscle pain, bone fractures, gastroesophageal reflux disease (GERD), dry mouth, weight loss, and rash. These are not all of the possible side effects of IQIRVO. Call your doctor for medical advice about side effects.

What other medications might interact with IQIRVO?

Tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. IQIRVO can affect the way certain medicines work. Certain medicines may affect the way IQIRVO works. If you take a bile acid binding resin, take IQIRVO at least 4 hours before or after you take your bile acid resin.

You are encouraged to report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. You may also report side effects to Ipsen Biopharmaceuticals, Inc. at 1-855-463-5127.

Please see full Prescribing Information.