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Información Importante de Seguridad
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How to start taking IQIRVO

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IQIRVO is taken with ursodiola or on its own in people unable to tolerate ursodiol.

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IQIRVO is taken orally as 
a small, 80 mg pill.

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One pill is taken daily, at the same time each day.

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IQIRVO can be taken with

or without food.

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If you are taking a bile acid binding resin for cholesterol, take IQIRVO at least 4 hours before or 4 hours after.

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Do not take more than 1 IQIRVO tablet per day, even if you miss a dose.

aUrsodeoxycholic acid, or ursodiol, may also be referred to as UDCA.

Staying on IQIRVO

Follow your treatment plan exactly as your doctor prescribes it and let them know immediately if you experience side effects

There’s often an adjustment period when starting a new medication. When it comes to your IQIRVO treatment, here are some helpful tips to keep in mind:

  • Try adding IQIRVO to your daily routine to help you stay on track—like when you brush your teeth or eat breakfast
  • Don’t take more than 1 IQIRVO tablet per day
  • Give your body time to adjust to your new medication—you may experience stomach-related side effects, but they’re usually not severe and tend to improve within 2 weeks
  • Don’t hesitate to reach out to your doctor with questions—they’ll advise you based on your specific needs
  • Remember what matters most—finding what works for you and being kind to yourself along the way
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What are your treatment goals?

Think about your treatment goals and what you’d like to get out of IQIRVO in your journey with primary biliary cholangitis (PBC). Motivate yourself to achieve your goals by:

  • Actively communicating with your doctor about your needs
  • Staying consistent with your new routine
  • Taking IQIRVO exactly as it is prescribed to give yourself the best chance to respond to treatment

Lean on your support system

As a progressive disease, PBC can be challenging in ways that aren’t obvious to others. Know that you’re not alone in your journey, and sharing how you feel with friends and family may help more than you know.

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Learn more about how IQIRVO can 
transform your PBC treatment journey.

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See how IPSEN CARES can help you on 
your IQIRVO treatment journey.

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Learn about side effects

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Indication and Important Safety Information

What is IQIRVO® used for?

IQIRVO is a prescription medicine used to treat primary biliary cholangitis (PBC) in combination with ursodeoxycholic acid (UDCA) in adults who have not responded well to UDCA, or used alone in patients unable to tolerate UDCA.

IQIRVO is not recommended for use in people who have symptoms or signs of advanced liver disease. It is not known if taking IQIRVO will improve your chance of survival or prevent liver decompensation.

It is not known if IQIRVO is safe and effective in children under 18 years of age.

What Warnings should I know about IQIRVO?

  • IQIRVO can cause muscle problems (myalgia, myopathy, rhabdomyolysis) and muscle pain that can be severe. Treatment with IQIRVO may cause muscle pain or worsen existing pain and can increase the level of an enzyme in your blood called creatine phosphokinase (CPK); both can be a sign of muscle damage. If there is new or worsening muscle pain, your healthcare provider may examine you and perform a blood test. Stop taking IQIRVO and call your healthcare provider right away if you have any of the following signs or symptoms: severe muscle pain, unexplained soreness, unexplained muscle weakness, or dark, reddish urine.
  • IQIRVO may increase the risk of bone fractures. Tell your healthcare provider about any bone fractures, or if you develop pain, or have changes in your ability to move around.
  • IQIRVO may cause harm to an unborn baby when taken during pregnancy. Women taking IQIRVO who can become pregnant should use effective birth control during treatment and for 3 weeks after the last dose of IQIRVO. Talk to your healthcare provider about birth control methods that may be right for you. Tell your healthcare provider right away if you become pregnant or think you may be pregnant.
  • IQIRVO can cause liver problems and abnormal liver blood test results. Your healthcare provider should do tests before starting and during treatment with IQIRVO to check your liver function. Tell your healthcare provider right away if you experience any of the following during treatment with IQIRVO: swelling of your stomach-area (abdomen), yellowing of your skin or whites of your eyes, black, tarry, or bloody stools, mental changes such as confusion, being sleepier than usual or harder to wake up, slurred speech, mood swings, or changes in personality, or coughing up or vomiting blood, or your vomit looks like coffee grounds. If you have severe stomach-area (abdomen) pain, nausea, vomiting, diarrhea, loss of appetite or weight loss, new or worsening fatigue, weakness, fever and chills, light-headedness, or less frequent urination, tell your healthcare provider right away.
  • Some people taking IQIRVO had allergic reactions, which may include rash, trouble breathing, itching, or swelling of your face, lips, tongue, or throat. If you experience any of these, stop taking IQIRVO, call your healthcare provider right away or go to the nearest hospital emergency room.
  • IQIRVO can cause blockage of the bile duct and may increase your risk of gallstones. Call your healthcare provider right away if you develop pain in the upper right stomach area or yellowing of the skin.

You should not use IQIRVO if you:

  • Have advanced liver disease.
  • Are pregnant or plan to become pregnant. IQIRVO can harm your unborn baby. You should not become pregnant during treatment with IQIRVO.
  • Are breastfeeding or plan to breastfeed. It is not known if IQIRVO passes into your breast milk. Talk with your healthcare provider about the best way to feed your baby if you take IQIRVO.

What are the side effects of IQIRVO?

The most common side effects of IQIRVO include weight gain, diarrhea, stomach pain, nausea, vomiting, joint pain, constipation, muscle pain, bone fractures, gastroesophageal reflux disease (GERD), dry mouth, weight loss, and rash. These are not all of the possible side effects of IQIRVO. Call your doctor for medical advice about side effects.

What other medications might interact with IQIRVO?

Tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. IQIRVO can affect the way certain medicines work. Certain medicines may affect the way IQIRVO works. If you take a bile acid binding resin, take IQIRVO at least 4 hours before or after you take your bile acid resin.

You are encouraged to report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. You may also report side effects to Ipsen Biopharmaceuticals, Inc. at 1-855-463-5127.

Please see full Prescribing Information.