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Información Importante de Seguridad
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Be proactive—stay ahead of rising alkaline phosphatase (ALP) numbers

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In primary biliary cholangitis (PBC), liver inflammation and buildup of toxins called bile acids can lead to 
damage and reduced liver function.

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PBC is progressive, meaning it can get worse over time. It can lead to permanent liver damage.

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A key goal of treatment is to lower ALP and maintain bilirubin within normal range.

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of people do not respond well enough to ursodiola and may require additional treatment.

aUrsodeoxycholic acid, or ursodiol, may also be referred to as UDCA.

ALP and bilirubin are measured with a blood test

Alkaline phosphatase (ALP)

ALP is a type of protein called an enzyme that is found in the liver and other parts of the body. It is a marker of liver health and is monitored regularly in people with PBC.

Bilirubin

Bilirubin is another substance found in the liver that is a marker of liver health.

Did you know?

PBC can be an invisible condition—symptoms are not connected to how severe your disease may be. Blood tests measuring ALP and bilirubin should be used to see if your current treatment plan is working for you.

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If you aren’t responding well enough to your current treatment, it may be time to reevaluate your treatment approach.

Doctor discussion guide

Need help discussing and evaluating your current treatment plan? Use the discussion guide below to help navigate the conversation with your doctor.

Starting the discussion can feel intimidating—but even a little preparation can make a big difference. You’ve got this!

Download guide
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“I encourage others living with PBC to empower and advocate for themselves with their doctor in managing their care.”

Wendy, person living with PBC
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Symptoms of PBC

Learn about how common symptoms impact people with PBC.
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Indication and Important Safety Information

What is IQIRVO® used for?

IQIRVO is a prescription medicine used to treat primary biliary cholangitis (PBC) in combination with ursodeoxycholic acid (UDCA) in adults who have not responded well to UDCA, or used alone in patients unable to tolerate UDCA.

IQIRVO is not recommended for use in people who have symptoms or signs of advanced liver disease. It is not known if taking IQIRVO will improve your chance of survival or prevent liver decompensation.

It is not known if IQIRVO is safe and effective in children under 18 years of age.

What Warnings should I know about IQIRVO?

  • IQIRVO can cause muscle problems (myalgia, myopathy, rhabdomyolysis) and muscle pain that can be severe. Treatment with IQIRVO may cause muscle pain or worsen existing pain and can increase the level of an enzyme in your blood called creatine phosphokinase (CPK); both can be a sign of muscle damage. If there is new or worsening muscle pain, your healthcare provider may examine you and perform a blood test. Stop taking IQIRVO and call your healthcare provider right away if you have any of the following signs or symptoms: severe muscle pain, unexplained soreness, unexplained muscle weakness, or dark, reddish urine.
  • IQIRVO may increase the risk of bone fractures. Tell your healthcare provider about any bone fractures, or if you develop pain, or have changes in your ability to move around.
  • IQIRVO may cause harm to an unborn baby when taken during pregnancy. Women taking IQIRVO who can become pregnant should use effective birth control during treatment and for 3 weeks after the last dose of IQIRVO. Talk to your healthcare provider about birth control methods that may be right for you. Tell your healthcare provider right away if you become pregnant or think you may be pregnant.
  • IQIRVO can cause liver problems and abnormal liver blood test results. Your healthcare provider should do tests before starting and during treatment with IQIRVO to check your liver function. Tell your healthcare provider right away if you experience any of the following during treatment with IQIRVO: swelling of your stomach-area (abdomen), yellowing of your skin or whites of your eyes, black, tarry, or bloody stools, mental changes such as confusion, being sleepier than usual or harder to wake up, slurred speech, mood swings, or changes in personality, or coughing up or vomiting blood, or your vomit looks like coffee grounds. If you have severe stomach-area (abdomen) pain, nausea, vomiting, diarrhea, loss of appetite or weight loss, new or worsening fatigue, weakness, fever and chills, light-headedness, or less frequent urination, tell your healthcare provider right away.
  • Some people taking IQIRVO had allergic reactions, which may include rash, trouble breathing, itching, or swelling of your face, lips, tongue, or throat. If you experience any of these, stop taking IQIRVO, call your healthcare provider right away or go to the nearest hospital emergency room.
  • IQIRVO can cause blockage of the bile duct and may increase your risk of gallstones. Call your healthcare provider right away if you develop pain in the upper right stomach area or yellowing of the skin.

You should not use IQIRVO if you:

  • Have advanced liver disease.
  • Are pregnant or plan to become pregnant. IQIRVO can harm your unborn baby. You should not become pregnant during treatment with IQIRVO.
  • Are breastfeeding or plan to breastfeed. It is not known if IQIRVO passes into your breast milk. Talk with your healthcare provider about the best way to feed your baby if you take IQIRVO.

What are the side effects of IQIRVO?

The most common side effects of IQIRVO include weight gain, diarrhea, stomach pain, nausea, vomiting, joint pain, constipation, muscle pain, bone fractures, gastroesophageal reflux disease (GERD), dry mouth, weight loss, and rash. These are not all of the possible side effects of IQIRVO. Call your doctor for medical advice about side effects.

What other medications might interact with IQIRVO?

Tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. IQIRVO can affect the way certain medicines work. Certain medicines may affect the way IQIRVO works. If you take a bile acid binding resin, take IQIRVO at least 4 hours before or after you take your bile acid resin.

You are encouraged to report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. You may also report side effects to Ipsen Biopharmaceuticals, Inc. at 1-855-463-5127.

Please see full Prescribing Information.